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isotope effect

 
   
Any effect caused by the substitution of one isotope for another. Normally this substitution has little effect on the chemistry of an element, but there are minor effects. The most important results from substituting deuterium for hydrogen; the deuterated compound will react up to seven times slower, as a result of the lower zero-point energy of the bond to the heavier isotope. Such a large kinetic isotope effect indicates clearly that the bond to hydrogen is broken in the rate- limiting step of the reaction.  

 

 

 
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